关键词: 非小细胞肺癌, 血小板与淋巴细胞比值, 中性粒细胞与淋巴细胞比值, 淋巴细胞与单核细胞比值, 预后

Abstract: Objective：To assess the prognosis of patients with nonsmall cell lung cancer(NSCLC) by the ratio of platelet to lymphocyte ratio(PLR),neutrophil to lymphocyte ratio(NLR) and lymphocyte to monocyte ratio(LMR) before operation value.Methods：120 patients with NSCLC who underwent surgical treatment in Suqian People’s Hospital of Nanjing Gulou Hospital Group from January 2013 to January  2015 were selected.The receiver operating characteristic(ROC) curve was used to determine the critical values of PLR,NLR,and LMR,to compare the clinicopathological characteristics between different groups,and to analyze the factors affecting the prognosis of NSCLC patients.Results：The area under the ROC(AUC) of PLR,NLR,LMR and NSCLC patients’ overall survival(OS) was 0.706(95%CI:0.616～0.785),0.617(95%CI:0.523～0.704),0.658(95%CI:0.565～0.742),the critical values are 128.87,3.30,and 3.93,respectively.Cox regression analysis showed that age(HR:2.074,95%CI:0.760～2.669,P=0.036),TNM stage(HR:2.264,95%CI:1.054～4.862,P=0.036),PLR(HR:2.964,95%CI:1.003～8.762,P=0.049) are independent risk factors that affect the OS of NSCLC patients,age(HR:1.829,95%CI:1.031～3.246,P=0.039),TNM stage(HR:1.883,95%CI:1.065～3.329,P=0.030) was an independent risk factor affecting the diseasefree survival(DFS) of patients.Conclusion：The predictive value of preoperative PLR for the prognosis of NSCLC patients is better than that of NLR and LMR,or it can be used as a prognostic index.

Key words: nonsmall cell lung cancer, platelet to lymphocyte ratio, neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio, prognosis