干扰素诱导跨膜蛋白3、半乳糖凝集素-7和半乳糖凝集素-9表达与胸中段食管鳞癌改良Ivor lewis术后淋巴结转移性复发的关系

doi:10.3969/j.issn.1005-6483.2019.07.013

摘要/Abstract

摘要： 目的：探讨胸中段食管鳞癌（ESCC）干扰素诱导跨膜蛋白3（IFITM3）、半乳糖凝集素7（Galectin7）和Galectin9表达及与改良Ivorlewis术后淋巴结转移性复发的关系。方法：改良Ivorlewis手术治疗的胸中段食管癌病人91例，采用免疫组织化学法（IHC）检测肿瘤组织及癌旁正常组织中IFITM3、Galectin7、Galectin9表达情况，并分析其与术后淋巴结转移性复发的关系。结果：ESCC病灶组织中IFITM3、Galectin7表达量高于癌旁组织，Galectin9表达量低于癌旁组，差异有统计学意义（P＜0.05）；ESCC病灶组织中IFITM3、Galectin7、Galectin9阳性表达率分别为57.14%、65.93%和60.44%，癌旁组织分别为13.19%、5.49%和89.01%，两组比较差异有统计学意义（P＜0.05）。随着TNM分期的升高，IFITM3、Galectin7的阳性表达率也明显升高（P＜0.05）。术后3年内有37例（40.66%）淋巴结复发性转移，TNM分期、IFITM3和Galectin7过表达、Galectin9欠表达是淋巴结转移性复发的独立危险因素（P＜0.05）。结论：IFITM3、Galectin7过表达和Galectin9欠表达参与了胸中段ESCC的发生及发展，且与改良Ivorlewis术后淋巴结转移性复发密切相关。

关键词: 食管鳞癌, 改良Ivorlewis手术, 淋巴转移复发, 干扰素诱导跨膜蛋白3, 半乳糖凝集素

Abstract: Objective：To investigate the expression of interferoninduced transmembrane protein 3（IFITM3），Galectin7 and Galectin9 of midthoracic esophageal squamous cell carcinoma（ESCC）and relationship with lymphatic metastatic recurrence after modified Ivorlewis esophagectomy.Methods：91 patients with midthoracic ESCC underwent modified Ivorlewis esophagectomy with twofield lymphadenectomy were enrolled，the expression profile of IFITM3，Galectin7，Galectin9 protein of samples of the ESCC tissues and paracarcinoma tissues were detected by immunohistochemistry（IHC），the relationship of IFITM3，Galectin7，Galectin9 expression and lymphatic metastatic recurrence was analyzed.Results：The expression of IFITM3 and Galectin7 in samples of ESCC tissues was significantly higher than the paracarcinoma tissues，while the expression of Galectin9 was significantly lower than the paracarcinoma tissues，the differences were statistically significant（P＜0.05）.The positive expression rate of IFITM3，Galectin7，Galectin9 in samples of ESCC tissues was 57.14%，65.93% and 60.44%，respectively；and the positive expression rate was 13.19%，5.49% and 89.01% in samples of paracarcinoma tissues，respectively.Tthe difference was statistically significant（P＜0.05）.With the increase of TNM stage，the positive expression rates of IFITM3 and Galectin7 were significantly increased（P＜0.05）.There was 37 patients（40.66%）with lymphatic metastatic recurrence within 3 years after surgery，the TNM stage，IFITM3 and Galectin7 overexpression，and Galectin9 underexpression were independent risk factors forymphatic metastatic recurrence（P＜0.05）.Conclusion：IFITM3，Galectin7 overexpression and Galectin9 underexpression might involve in occurrence and development of the midthoracic ESCC.It may be closely related to improved lymph node metastasis after Ivorlewis surgery.

Key words: esophageal squamous cell carcinoma, modified Ivorlewis esophagectomy, lymphatic metastatic recurrence, interferoninduced transmembrane protein 3, galectin

孙之昀, 邹志强. 干扰素诱导跨膜蛋白3、半乳糖凝集素-7和半乳糖凝集素-9表达与胸中段食管鳞癌改良Ivor lewis术后淋巴结转移性复发的关系[J]. 临床外科杂志, 2019, 27(7): 581-584.

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